GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway
Summary: Molecular mechanisms mediating cardiac hypertrophy by glucose metabolism are incompletely understood.Hexosamine biosynthesis pathway (HBP), an accessory pathway of glycolysis, is known to be involved in the attachment of O-linked N-acetylglucosamine motif (O-GlcNAcylation) read more to proteins, a post-translational modification.We here de